Origami authentically merges art and design with mathematical theory, algorithms, and technology. Math is central to learning in STEM, and is a language shared by STEM, art and design (http://cjvrose.com/wp-content/uploads/2012/03/stem-to-steam-report.pdf).
Origami artist Dr. Robert J. Lang of Alamo, California, also a physicist and engineer with expertise in R&D, has written and spoken extensively on these ideas (http://www.langorigami.com/science/science.php). Paper folding artist Michael LaFosse of Origamido Studio (http://origamido.com) in Haverhill, Massachusetts, is a biologist by training and uses organisms as subjects for his art.
There are even conferences about this type of work. The Sixth International Conference on Origami in Science, Mathematics, and Education (6OSME) (http://www.origami.gr.jp/6osme/) will take place at lovely Yayoi Auditorium on the Hongo campus of The University of Tokyo (http://www.u-tokyo.ac.jp/en/) in August 2014. The conference is currently taking submissions from “art, design, mathematics, science, computer science, engineering, liberal arts, history, education, and other fields and their intersections.”
Paper folding is something that interests undergraduates, as evidenced by the origami club at MIT, OrigaMIT (http://origamit.scripts.mit.edu/index.php), so it may suggest a new type of active learning for incorporation into university courses, especially those in math and engineering.